diff --git a/python/flatbuffers/flexbuffers.py b/python/flatbuffers/flexbuffers.py
index aaa02fdaf..34d42a698 100644
--- a/python/flatbuffers/flexbuffers.py
+++ b/python/flatbuffers/flexbuffers.py
@@ -75,7 +75,7 @@ class BitWidth(enum.IntEnum):
   @staticmethod
   def F(value):
     """Returns the `BitWidth` to encode floating point value."""
-    if struct.unpack('f', struct.pack('f', value))[0] == value:
+    if struct.unpack('<f', struct.pack('<f', value))[0] == value:
       return BitWidth.W32
     return BitWidth.W64
 
@@ -95,20 +95,20 @@ F = {4: 'f', 8: 'd'}  # Floating point formats
 
 
 def _Unpack(fmt, buf):
-  return struct.unpack(fmt[len(buf)], buf)[0]
+  return struct.unpack('<%s' % fmt[len(buf)], buf)[0]
 
 
 def _UnpackVector(fmt, buf, length):
   byte_width = len(buf) // length
-  return struct.unpack('%d%s' % (length, fmt[byte_width]), buf)
+  return struct.unpack('<%d%s' % (length, fmt[byte_width]), buf)
 
 
 def _Pack(fmt, value, byte_width):
-  return struct.pack(fmt[byte_width], value)
+  return struct.pack('<%s' % fmt[byte_width], value)
 
 
 def _PackVector(fmt, values, byte_width):
-  return struct.pack('%d%s' % (len(values), fmt[byte_width]), *values)
+  return struct.pack('<%d%s' % (len(values), fmt[byte_width]), *values)
 
 
 def _Mutate(fmt, buf, value, byte_width, value_bit_width):
diff --git a/tests/py_flexbuffers_test.py b/tests/py_flexbuffers_test.py
index 6696b3e23..fcd17faaa 100644
--- a/tests/py_flexbuffers_test.py
+++ b/tests/py_flexbuffers_test.py
@@ -74,15 +74,15 @@ def int_sizes(value):
 
 
 def int_bytes(value, byte_width):
-  return struct.pack({1: 'b', 2: 'h', 4: 'i', 8: 'q'}[byte_width], value)
+  return struct.pack('<%s' % {1: 'b', 2: 'h', 4: 'i', 8: 'q'}[byte_width], value)
 
 
 def uint_bytes(value, byte_width):
-  return struct.pack({1: 'B', 2: 'H', 4: 'I', 8: 'Q'}[byte_width], value)
+  return struct.pack('<%s' % {1: 'B', 2: 'H', 4: 'I', 8: 'Q'}[byte_width], value)
 
 
 def float_bytes(value, byte_width):
-  return struct.pack({4: 'f', 8: 'd'}[byte_width], value)
+  return struct.pack('<%s' % {4: 'f', 8: 'd'}[byte_width], value)
 
 
 def min_value(type_, byte_width):
diff --git a/tests/py_test.py b/tests/py_test.py
index 623760b06..672dd3201 100644
--- a/tests/py_test.py
+++ b/tests/py_test.py
@@ -701,18 +701,18 @@ def CheckReadBuffer(buf, offset, sizePrefix=False, file_identifier=None):
     import numpy as np
 
     asserter(monster.InventoryAsNumpy().sum() == 10)
-    asserter(monster.InventoryAsNumpy().dtype == np.dtype('uint8'))
+    asserter(monster.InventoryAsNumpy().dtype == np.dtype('<u1'))
 
     VectorOfLongs = monster.VectorOfLongsAsNumpy()
-    asserter(VectorOfLongs.dtype == np.dtype('int64'))
+    asserter(VectorOfLongs.dtype == np.dtype('<i8'))
     for i in range(5):
       asserter(VectorOfLongs[i] == 10**(i * 2))
 
     VectorOfDoubles = monster.VectorOfDoublesAsNumpy()
-    asserter(VectorOfDoubles.dtype == np.dtype('float64'))
-    asserter(VectorOfDoubles[0] == np.finfo('float64').min)
+    asserter(VectorOfDoubles.dtype == np.dtype('<f8'))
+    asserter(VectorOfDoubles[0] == np.finfo('<f8').min)
     asserter(VectorOfDoubles[1] == 0.0)
-    asserter(VectorOfDoubles[2] == np.finfo('float64').max)
+    asserter(VectorOfDoubles[2] == np.finfo('<f8').max)
 
   except ImportError:
     # If numpy does not exist, trying to get vector as numpy
@@ -857,33 +857,33 @@ class TestFuzz(unittest.TestCase):
           check(table, 'bool', self.boolVal,
                 table.GetSlot(f, False, N.BoolFlags))
         elif choice == 1:
-          check(table, 'int8', self.int8Val, table.GetSlot(f, 0, N.Int8Flags))
+          check(table, '<i1', self.int8Val, table.GetSlot(f, 0, N.Int8Flags))
         elif choice == 2:
-          check(table, 'uint8', self.uint8Val,
+          check(table, '<u1', self.uint8Val,
                 table.GetSlot(f, 0, N.Uint8Flags))
         elif choice == 3:
-          check(table, 'int16', self.int16Val,
+          check(table, '<i2', self.int16Val,
                 table.GetSlot(f, 0, N.Int16Flags))
         elif choice == 4:
-          check(table, 'uint16', self.uint16Val,
+          check(table, '<u2', self.uint16Val,
                 table.GetSlot(f, 0, N.Uint16Flags))
         elif choice == 5:
-          check(table, 'int32', self.int32Val,
+          check(table, '<i4', self.int32Val,
                 table.GetSlot(f, 0, N.Int32Flags))
         elif choice == 6:
-          check(table, 'uint32', self.uint32Val,
+          check(table, '<u4', self.uint32Val,
                 table.GetSlot(f, 0, N.Uint32Flags))
         elif choice == 7:
-          check(table, 'int64', self.int64Val,
+          check(table, '<i8', self.int64Val,
                 table.GetSlot(f, 0, N.Int64Flags))
         elif choice == 8:
-          check(table, 'uint64', self.uint64Val,
+          check(table, '<u8', self.uint64Val,
                 table.GetSlot(f, 0, N.Uint64Flags))
         elif choice == 9:
-          check(table, 'float32', self.float32Val,
+          check(table, '<f4', self.float32Val,
                 table.GetSlot(f, 0, N.Float32Flags))
         elif choice == 10:
-          check(table, 'float64', self.float64Val,
+          check(table, '<f8', self.float64Val,
                 table.GetSlot(f, 0, N.Float64Flags))
         else:
           raise RuntimeError('unreachable')